Some of the most studied growth hormone secretagogues include Ipamorelin and CJC-1295. CJC-1295 targets the growth hormone-releasing hormone (GHRH) receptor, while Ipamorelin works on the ghrelin receptor. Since high and broadened GH peaks may operate synergistically to create more significant benefits while reducing adverse effects, combining these peptides is expected in the study. Thankfully, the price of Ipamorelin and CJC-1295 has not increased while the demand for these peptides has grown.
Price of Ipamorelin/CJC-1295
Researchers might interpret the pricing model for CJC 1295 & Ipamorelin in two ways. For one thing, combining two GH secretagogues can seem excessive. Ultimately, both will lead to physiological increases in GH levels, boosting muscle and bone growth while reducing fat mass. Researchers may keep costs to a minimum by opting for the very selective Ipamorelin with its improved bone advantages or the similarly selective CJC-1295 with its lengthy half-life.
On the other side, one may argue that the price of Ipamorelin/CJC-1295 is not only reasonable but downright cheap when both peptides are used together. CJC-1295, when administered alone, results in amplified peaks, but when combined with Ipamorelin, it raises the baseline, leading to even more amplified peaks and deeper troughs. Together, the peptides boost GH levels to heights that are impossible to reach with either peptide alone, even at very high dosages. Hence, the advantages of much-increased growth hormone production can only be studied using the Ipamorelin/CJC-1295 combo, the cheapest and only method to acquire it.
Supplemental Secretagogues for Growth Hormone
Of course, many would argue that the high price of Ipamorelin/CJC-1295 isn’t warranted since alternative growth hormone secretagogues may be utilized in conjunction at a much cheaper cost. Once again, this is true and untrue at the same time. Although various combinations of GHRH and ghrelin analogs may also be helpful, they often carry a higher risk of adverse effects. This is because, unlike Ipamorelin and CJC-1295, they are not as selective in binding to their intended receptors. CJC-1295 is second only to Ipamorelin in selectivity among growth hormone secretagogues. Considering that both peptides’ adverse effect profiles are minimal even when combined, the cost-benefit analysis favors Ipamorelin and CJC-1295.
Combining Unintended Consequences
Neither Ipamorelin nor CJC-1295 can be said to have any significant adverse effects. To put it more accurately, they do not have direct impacts but rather indirect or tertiary ones. The benefits of Ipamorelin and CJC-1295 beyond the typical GH effects of increased lean body mass and reduced fat mass are not unintended side effects produced by activity at additional receptors but rather prolonged specific effects of GH axis activation.
A significant unintended consequence of Ipamorelin is an improvement in bone density. The peptide has been used for a long time because of its proven capacity to prevent bone loss by boosting bone growth and mineralization by a factor of four. This is especially effective in both pathologic stages of bone loss, such as glucocorticoid medication, and in physiologic bone loss that arises from aging. Compared to other GH secretagogues, Ipamorelin has been demonstrated to have the most favorable effects on bone health and remodeling.
CJC-1295 helps restore regular GH pulsatile release in pathological conditions without interfering with the natural rhythm of GH release. This is significant since animal studies have shown that pulsatile GH release is essential for healthy development and aids in regulating the correct release of other hormones. Therefore, CJC-1295 is a kind of regulatory peptide that aids in maintaining healthy pituitary gland activity.
When combined, Ipamorelin and CJC-1295’s secondary effects provide a degree of benefit seldom observed with synergistic peptide combinations. Secondary benefits such as increased bone formation and control of the hypothalamic-pituitary-adrenal axis are virtually as beneficial as the main effects of increased muscle mass and fat loss. Thanks to this synergy, the benefits of Ipamorelin and CJC-1295 in treatment appear much more significant.